Dissecting Causal Links Between Gut Microbiota, Inflammatory Cytokines, and Parkinson's Disease: A Mendelian Randomization Study.

ABSTRACT:

Background

The association between gut microbiota (GM) and Parkinson's disease (PD) has been well established, but whether there is a causal relationship between the two and whether inflammatory cytokines (ICs) act as mediators remain unclear.

Methods

We utilized the summary databases of large-scale genome-wide association studies (GWAS) conducting Mendelian randomization (MR) analyses to investigate the causal relationships between GM, ICs, and PD. The inverse-variance weighted (IVW) method was primarily used to identify GM and ICs associated with PD and to examine the mediating role of ICs, supplemented by MR Egger and weighted median.

Results

Through MR analysis, we identified three positive causal relationships and six negative causal relationships between GM and

SUBMITTER: Caiyun M 

PROVIDER: S-EPMC11603428 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature