Dissecting non-B DNA structural motifs in untranslated regions of eukaryotic genomes.

ABSTRACT: The untranslated regions (UTRs) of genes significantly impact various biological processes, including transcription, posttranscriptional control, mRNA stability, localization, and translation efficiency. In functional areas of genomes, non-B DNA structures such as cruciform, curved, triplex, G-quadruplex, and Z-DNA structures are common and have an impact on cellular physiology. Although the role of these structures in cis-regulatory regions such as promoters is well established in eukaryotic genomes, their prevalence within UTRs across different eukaryotic classes has not been extensively documented. Our study investigated the prevalence of various non-B DNA motifs within the 5' and 3' UTRs across diverse eukaryotic species. Our comparative analysis encompassed the 5'-UTRs and 3'UTRs of 3

SUBMITTER: Gummadi ASC 

PROVIDER: S-EPMC11603647 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature