Histamine H₃ receptor inverse agonists/antagonists influence intra-regional cortical activity and inter-regional synchronization during resting state: an exploratory cortex-wide imaging study in mice.

ABSTRACT: The histaminergic system plays a key role in modulating learning and memory, wakefulness, and energy balance. Histamine H₃ receptors constitutively inhibit the synthesis and release of histamine and other neurotransmitters. Therefore, H₃ receptor inverse agonists/antagonists increase the synthesis and release of these neurotransmitters, enhancing cognitive functions, including memory consolidation and retrieval. Spontaneous neural activity across the cerebral cortex is essential for cognitive function, including memory consolidation. Abnormal spontaneous activity has, in fact, been associated with cognitive dysfunctions and psychiatric disorders. Given the cognitive improvement achieved with the use of H₃ receptor inverse agonists/antagonists, we examined t

SUBMITTER: Kaita S 

PROVIDER: S-EPMC11603655 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature