Zika virus encephalitis causes transient reduction of functional cortical connectivity.

ABSTRACT:

Significance

Determining the long-term cognitive impact of infections is clinically challenging. Using functional cortical connectivity, we demonstrate that interhemispheric cortical connectivity is decreased in individuals with acute Zika virus (ZIKV) encephalitis. This correlates with decreased presynaptic terminals in the somatosensory cortex. During recovery from ZIKV infection, presynaptic terminals recover, which is associated with recovered interhemispheric connectivity. This supports the contribution of synapses in the cortex to functional networks in the brain, which can be detected by widefield optical imaging. Although myeloid cell and astrocyte numbers are still increased during recovery, RNA transcription of multiple proinflammatory cytokines that increase during acute

SUBMITTER: Agner SC 

PROVIDER: S-EPMC11603678 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature