B cell c-Maf signaling promotes tumor progression in animal models of pancreatic cancer and melanoma.

ABSTRACT:

Background

The role of B cells in antitumor immunity remains controversial, with studies suggesting the protumor and antitumor activity. This controversy may be due to the heterogeneity in B cell populations, as the balance among the subtypes may impact tumor progression. The immunosuppressive regulatory B cells (Breg) release interleukin 10 (IL-10) but only represent a minor population. Additionally, tumor-specific antibodies (Abs) also exhibit antitumor and protumor functions dependent on the Ab isotype. Transcription factor c-Maf has been suggested to contribute to the regulation of IL-10 in Breg, but the role of B cell c-Maf signaling in antitumor immunity and regulating Ab responses remains unknown.

Methods

Conditional B cell c-Maf knockout (KO) and control mice were us

SUBMITTER: Zhong Q 

PROVIDER: S-EPMC11603694 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature