Renal response status to predict long-term renal survival in patients with lupus nephritis: results from the Toronto Lupus Cohort.

ABSTRACT:

Objective

To evaluate modified versions of the Belimumab International Study in Lupus Nephritis (BLISS-LN) belimumab study primary efficacy renal response (mPERR) and complete renal response (mCRR) criteria (excluding mandatory corticosteroid tapering) as predictors of real-world, long-term renal outcomes among patients with lupus nephritis (LN).

Methods

This retrospective, observational study (GSK Study 212866) used deidentified data between 1970 and 2015 from the University of Toronto Lupus Cohort from adults diagnosed with systemic lupus erythematosus and biopsy-proven Class III±V, IV±V or V LN. At 24 months postbiopsy, patients were retrospectively indexed as responders/non-responders based on mPERR (estimated glomerular filtration rate (eGFR) ≤20% below biopsy value/≥60

SUBMITTER: Urowitz M 

PROVIDER: S-EPMC11603717 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature