Impact of longitudinal changes in serum uric acid levels and weight gain on new-onset atrial fibrillation-The Nishimura Health Survey: a retrospective cohort study.

ABSTRACT:

Objective

Uric acid (UA) and obesity are significant risk factors for new-onset atrial fibrillation (AF). Based on the pathogenesis mechanisms of new-onset AF involving obesity and UA, it is possible that UA and weight gain may interact with each other. We investigated the impact of UA and weight gain on new-onset AF using a simple measure of weight change over time, 'weight gain of ≥10 kg after age 20'.

Design

A retrospective cohort study.

Setting and participants

We retrospectively analysed 16 444 Japanese aged over 30 without AF from a cohort of employees undergoing annual health check-up from 2 April 2013 to 30 April 2022. We conducted a landmark survival analysis to assess the impact of longitudinal changes in UA and obesity on new-onset AF. Weight gain was defin

SUBMITTER: Munakata J 

PROVIDER: S-EPMC11603741 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature