Exploring the link between dietary patterns and gastric adenocarcinoma in Brazil: a mediation analysis.

ABSTRACT:

Background

The causal pathway between different dietary patterns (DPs) and gastric adenocarcinoma (GA) remains largely unexplored. The study aimed to identify DPs and evaluate how selected nutrients mediate the relationship between DPs and GA.

Methods

This multicenter case-control study in Brazil involved 1751 participants (600 cases, 377 endoscopic controls, and 774 hospital controls). DPs were identified through exploratory factor analysis. A counterfactual-based mediation analysis was performed to decompose the total effect of DPs on GA into direct and indirect effects mediated by saturated fatty acids, added sugars, total fiber, and sodium intakes. Effects were expressed as ORs and 95% CIs.

Results

Two DPs were identified-"unhealthy dietary pattern" (UDP) and "hea

SUBMITTER: Silva ARC 

PROVIDER: S-EPMC11603788 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature