Taprenepag restores maternal-fetal interface homeostasis for the treatment of neurodevelopmental disorders.

ABSTRACT:

Background and purpose

Neurodevelopmental disorders (NDDs) are characterized by abnormalities in brain development and neurobehaviors, including autism. The maternal-fetal interface (MFI) is a highly specialized tissue through which maternal factors affect fetal brain development. However, limited research exists on restoring and maintaining MFI homeostasis and its potential impact on NDDs. This study explores the role of placental indoleamine 2,3-dioxygenase (IDO-1) in MFI homeostasis and fetal brain development.

Experimental approach

The maternal-fetal barrier was disrupted by sodium valproate (VPA) in pregnant mice, whose offspring show typical autism-like behaviors. Ultrastructural analysis and flow cytometric analysis were conducted to observe the morphological and immu

SUBMITTER: Wang K 

PROVIDER: S-EPMC11603931 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature