Mortality in septic patients treated with short-acting betablockers: a comprehensive meta-analysis of randomized controlled trials.

ABSTRACT:

Background

Treatment with short-acting betablockers in septic patients remains controversial. Two recent large multicenter trials have provided additional evidence on this therapeutic approach. We thus performed a meta-analysis, including the most recent data, to evaluate the potential impacts of treatment with short-acting betablockers on mortality in adult septic patients.

Methods

The data search included PubMed, Web of Science, ClinicalTrials.gov and the Cochrane Library. A meta-analysis of all eligible peer-reviewed studies was performed in accordance with the PRISMA statement. Only randomized, controlled studies with valid classifications of sepsis and intravenous treatment with short-acting betablockers (landiolol or esmolol) were included. Short-term mortality served

SUBMITTER: Alexandru MG 

PROVIDER: S-EPMC11603935 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature