Head-to-head comparison of tau PET tracers [¹⁸F]PI-2620 and [¹⁸F]RO948 in non-demented individuals with brain amyloid deposition: the TAU-PET FACEHBI cohort.

ABSTRACT:

Background

Second-generation tau tracers for positron emission tomography (PET) show high affinity for paired helical filaments tau deposits characteristic of Alzheimer´s disease and low off-target binding. Differences in their chemical structure though may lead to variations in their regional tau uptake and off-target signal. In this work, we aimed to compare the in-vivo uptake of tau tracers [¹⁸F]PI-2620 and [¹⁸F]RO948 in the early stages of the AD continuum.

Methods

Data from the TAU-PET FACEHBI clinical trial (EUDRA-CT 2021-000473-83) were analyzed. All participants were non-demented and underwent tau imaging with [¹⁸F]PI-2620 and [¹⁸F]RO948 PET within 3 months, amyloid imaging with [¹⁸F]Florbetaben and brain magneti

SUBMITTER: Tonietto M 

PROVIDER: S-EPMC11603960 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature