Integrated analysis of per- and polyfluoroalkyl substances and plasma lipidomics profiles in multi-ethnic Asian subjects for exposome research.

ABSTRACT:

Background

Perfluoroalkyl and polyfluoroalkyl substances (PFAS) exposure has been associated with metabolic diseases, however, the underlying molecular pathogenesis remains to be understood. Integrated PFAS and lipidomic analysis has the potential to identify alterations in lipid metabolism pathways for exposome research.

Methods

A targeted LC-MS/MS method was developed for the quantification of 14 PFAS from human plasma samples (n = 96). Concurrently, high coverage lipidomics was conducted for the quantification of 665 lipid species in the same plasma samples. Linear regression models were implemented to study the association of PFAS with plasma lipidome.

Results

Women had lower levels of PFAS compared to men and Asian-Indians had lower levels of PFAS compared to bot

SUBMITTER: Narasimhan K 

PROVIDER: S-EPMC11603991 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature