Nebulized alteplase in coronavirus disease 2019 pneumonia: a case series.

ABSTRACT:

Background

Many patients with severe coronavirus disease 2019 pneumonia exhibit signs of microthrombosis. Previous studies discussed intravenous fibrinolytic agents as potential add-on therapy in these patients. Therefore, we propose the inhalative administration of fibrinolytics as a possible safer alternative.

Case presentation

This case series describes five white male patients, aged 51-78 years, treated with off-label inhalation of alteplase between November and December 2020. All patients suffered from severe severe acute respiratory syndrome coronavirus 2 infection with respiratory failure. Pulmonary embolism was ruled out by pulmonary angiogram in computed tomography scans, and all patients showed signs of coronavirus disease 2019 pneumonia. Four patients improved cli

SUBMITTER: Milacek C 

PROVIDER: S-EPMC11603999 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature