Mechanism of jianxin granules in the treatment of heart failure based on proteomics and metabolomics.

ABSTRACT:

Background

Heart failure (HF) is associated with high mortality and rehospitalization rates, highlighting the need for novel therapeutic approaches. Jianxin (JX) granules, a Traditional Chinese Medicine formulation, have been patented for the treatment of HF. However, the specific therapeutic effects and underlying mechanisms of JX granules have not been fully elucidated. This study aimed at investigating the effects and mechanism of JX granules in the treatment of HF based on proteomics and metabolomic profiling.

Methods

HF model was established in rats by ligation of left coronary artery. The successfully modeled rats were randomly divided into three groups: the model group, the JX granules group, and Sacubitril/Valsartan (S/V) group. Four weeks after treatment, left ventr

SUBMITTER: Yongzhong C 

PROVIDER: S-EPMC11604013 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature