AmpC β-lactamases detected in Southeast Asian <i>Escherichia coli</i> and <i>Klebsiella pneumoniae</i>.

ABSTRACT:

Objectives

AmpC β-lactamases are neglected compared with ESBL as a cause of third-generation cephalosporin (3GC) resistance in Enterobacterales in low- and middle-income countries and the burden is unknown. The aim of this study was to investigate the presence of AmpC β-lactamase-producing Escherichia coli and Klebsiella pneumoniae in clinical specimens from three clinical research laboratories in Southeast Asia.

Methods

Stored clinical isolates of E. coli and K. pneumoniae resistant to ceftriaxone or ceftazidime or cefpodoxime and ESBL confirmation test negative were screened using MASTDISCS AmpC, ESBL and Carbapenemase Detection Set-D72C. Short-read WGS was performed to identify ampC genes.

Results

Of 126 isolates collected between

SUBMITTER: Roberts T 

PROVIDER: S-EPMC11604056 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature