Exploring robustness of hybrid membranes under high hydrostatic pressure and temperature.

ABSTRACT: Bacterial membranes are typically composed of ester-bonded fatty acid (FA), while archaeal membranes consist of ether-bonded isoprenoids, differentiation referred to as the 'lipid divide'. Some exceptions to this rule are bacteria harboring ether-bonded membrane lipids. Previous research engineered the bacterium Escherichia coli to synthesize archaeal isoprenoid-based ether-bonded lipids together with the bacterial FA ester-linked lipids, showing that heterochiral membranes are stable and more robust to temperature, cold shock, and solvents. However, the impact of ether-bonded lipids, either bacterial or archaeal, on membrane robustness, remains unclear. Here, we investigated the robustness, as survival after shock, of E. coli synthesizing either archaeal or bacterial ether-b

SUBMITTER: Tamby A 

PROVIDER: S-EPMC11604127 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature