Targeting Endogenous Tau in Seeded Tauopathy Models Inhibits Tau Spread.

ABSTRACT: The transmission of tau pathology has been proposed as one of the major mechanisms for the spatiotemporal spreading of tau pathology in neurodegenerative diseases. Over the last decade, studies have demonstrated that targeting total or pathological tau using tau antibodies can mitigate the development of tau pathology in tauopathy or Alzheimer's disease (AD) mouse models, and multiple tau immunotherapy agents have progressed to clinical trials. Tau antibodies are believed to inhibit the internalization of pathologic seeds and/or block seed elongation after seed internalization. To further address the mechanism of tau antibody inhibition of pathological spread, we conducted immunotherapy studies in mouse primary neurons and wild-type mice (females) seeded with AD patient-derived tau to indu

SUBMITTER: Jang E 

PROVIDER: S-EPMC11604146 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature