Association between warfarin use and thromboembolic events in patients post-Fontan operation: propensity-score overlap weighting analyses.

ABSTRACT:

Objectives

The appropriate antithrombotic regimen after a Fontan operation is yet to be elucidated. Hence, this study aimed to compare the incidence of thromboembolic events in patients with and without receiving warfarin for thromboprophylaxis in a large post-Fontan population.

Methods

This retrospective cohort study used data from the Diagnosis Procedure Combination database in Japan between April 2011 and March 2022. We identified all patients who underwent a Fontan operation and excluded those who were born before 2010, died during the hospitalization or received mechanical heart replacement. Propensity score overlap weighting was performed between patients discharged with warfarin (with or without aspirin) and the control group (only aspirin or neither aspirin nor warfa

SUBMITTER: Maki W 

PROVIDER: S-EPMC11604171 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature