Telomerase RNA component knockout exacerbates <i>Staphylococcus aureus</i> pneumonia by extensive inflammation and dysfunction of T cells.

ABSTRACT: The telomerase RNA component (Terc) constitutes a non-coding RNA critical for telomerase function, commonly associated with aging and pivotal in immunomodulation during inflammation. Our study unveils heightened susceptibility to pneumonia caused by Staphylococcus aureus (S. aureus) in Terc knockout (Terc^ko/ko) mice compared to both young and old infected counterparts. The exacerbated infection in Terc^ko/ko mice correlates with heightened inflammation, manifested by elevated interleukin-1β (IL-1β) levels and activation of the NLR family pyrin domain containing 3 (NLRP3) inflammasome within the lung. Employing mRNA sequencing methods alongside in vitro analysis of alveolar macrophages (AMs) and T cells, our study elucidates a compelling corr

SUBMITTER: Reisser Y 

PROVIDER: S-EPMC11604217 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature