Transcriptome Analysis of Platelet-Rich Plasma-Treated Osteoarthritic Chondrocyte.

ABSTRACT: As a blood-derived biomaterial, platelet-rich plasma (PRP) has been considered a potential therapy and tried in knee and hip osteoarthritis with beneficial effects as an anti-inflammatory and potent regenerative agent. To better understand the substantial effect of PRP on chondrocytes in an inflammatory environment, we analyzed the transcriptome profile by RNA sequencing (RNA-seq) after PRP administration in IL-1β-treated osteoarthritic chondrocytes which were isolated from human knee articular cartilage tissue. A total of 24,424 genes were analyzed, and significant changes in expression were observed for 226 genes in the control (CTL) versus IL-1β group and 300 genes in the IL-1β versus IL-1β+PRP group. The Top 20 significantly upregulated and downregulated gen

SUBMITTER: Suh DK 

PROVIDER: S-EPMC11604281 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature