Determining Disease Activity and Glucocorticoid Response in Thyroid-Associated Ophthalmopathy: Preliminary Study Using Dynamic Contrast-Enhanced MRI.

ABSTRACT:

Objective

To assess the role of dynamic contrast-enhanced (DCE)-MRI of the extraocular muscles (EOMs) for determining the activity of thyroid-associated ophthalmopathy (TAO) and treatment response to glucocorticoids (GCs).

Materials and methods

We prospectively enrolled 65 patients with TAO (41 active, 82 eyes; 24 inactive, 48 eyes). Twenty-two active patients completed the GC treatment and follow-up assessment, including 15 patients (30 eyes) and 7 patients (14 eyes), defined as responsive and unresponsive, respectively. Model-free (time to peak [TTP], area under the curve [AUC], and Slope_max) and model-based (K^trans, K_ep, and V_e) parameters of EOMs in embedded simplified histogram analyses were calculated and compared between gro

SUBMITTER: Hu H 

PROVIDER: S-EPMC11604342 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature