Pericardial Fluid of Patients With Coronary Artery Disease Can Drive Fibrosis Via TGF-Beta Pathway.

ABSTRACT: Human pericardial fluid (PF) is a rich reservoir of biologically active markers. The acellular compartment of PF can drive cardiac fibroblast activity in vitro. This process is mediated through the transforming growth factor-β pathway. Of clinical importance, the PF of patients with coronary artery disease has an increased profibrotic capacity compared with the PF of patients without coronary artery disease.

SUBMITTER: Fatehi Hassanabad A 

PROVIDER: S-EPMC11604402 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature