Nuclear Expression of Dynamin 2 Is Associated With Tumor Aggressiveness in Bladder Cancer Patients: A Bioinformatics and Experimental Approach.

ABSTRACT:

Background

Dynamin 2 (DNM2) is aberrantly expressed in different malignancies and exerts a function in tumor progression.

Aims

This study, for the first time, aimed to evaluate the clinical and prognostic value of DNM2 in the pathophysiology of bladder cancer using bioinformatics analysis and experimental evaluation.

Methods and results

We analyzed gene expression of DNM2 in bladder tumor by GEPIA2 and GENT2 platforms. Cluster subnetworks were recognized from the protein-protein interaction (PPI) network using the MCODE plugin to screen the key genes. Subsequently, the pathway enrichment analysis was evaluated. Then, the immunohistochemical examination was conducted on 209 paraffin-embedded bladder cancer samples to determine the expression pattern and clinical import

SUBMITTER: Razmi M 

PROVIDER: S-EPMC11604598 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature