A nested case-control study on the association of gut virome in early pregnancy and gestational diabetes mellitus.

ABSTRACT:

Background

Recent studies have increasingly shown the connection between gut microbiome and gestational diabetes mellitus (GDM). However, no studies have explored the relationship between the gut virome and GDM, and the underlying mechanism remains unknown.

Methods

We performed a nested case-control study within a follow-up cohort, enrolling 51 patients with GDM and 51 healthy controls. Shotgun metagenomics sequencing was used to explore gut virome profiles during early pregnancy.

Results

Diversity analysis revealed no difference in the overall gut virome composition between two groups, however, we found greater abundance of Escherichia phage SH2026Stx1 (Q = 0.23), Enterobacteria phage mEp043 c-1 (Q = 0.21), crAssphage cr50_1 (Q</

SUBMITTER: Wu X 

PROVIDER: S-EPMC11604603 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature