Subtyping colorectal cancer based on septic shock-associated genes: prognosis and immune characteristics.

ABSTRACT:

Background

Sepsis and colorectal cancer (CRC) are leading causes of death. Given their mutual dependence for susceptibility, we used bioinformatics to explore potential connections between septic shock (SS) and CRC.

Methods

We identified 452 co-expressed genes between SS-related differential expression genes (SS-DEGs) and CRC patient-expressed genes (TCGA-CRC genes). CRC samples were categorized into two cluster subgroups through hierarchical clustering. We then compared the prognosis and immune landscapes of the two cluster subgroups through survival analysis, immune microenvironment analysis, and immune therapy response evaluation.

Results

Clustering analysis of the 452 CRC patient-expressed SS-DEGs identified two subtypes: SS-like CRC (SL-CRC) and non-SS-like CRC (

SUBMITTER: Zhao J 

PROVIDER: S-EPMC11604612 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature