Ligand-enabled Ni-catalysed dicarbofunctionalisation of alkenes with diverse native functional groups.

ABSTRACT: The transition metal-catalysed dicarbofunctionalisation of unactivated alkenes normally requires exogenous strong coordinated directing groups, thus reducing the overall reaction efficiency. Here, we report a ligand-enabled Ni(II)-catalysed dicarbofunctionalisation of unactivated alkenes with aryl/alkenyl boronic acids and alkyl halides as the coupling partners with a diverse range of native functional groups as the directing group. This dicarbofunctionalisation protocol provides an efficient and direct route towards vicinal 1,2-disubstituted alkanes using primary, secondary, tertiary amides, sulfonamides, as well as secondary and tertiary amines under redox-neutral conditions that are challenging to access through conventional methods. The key to the success of this reaction is the use of

SUBMITTER: Wang DM 

PROVIDER: S-EPMC11604661 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature