The Cough Response to Inhaled Mannitol in Healthy Subjects.

ABSTRACT:

Purpose

Inhaled mannitol induces bronchoconstriction and cough. This study aimed to describe the cough response to mannitol among healthy adult subjects.

Methods

125 healthy subjects (aged 18-82 years, 52% females, 50% skin prick test positive) underwent a mannitol test. The coughs were recorded both simultaneously and afterwards from video recordings by two researchers. Three indices were evaluated: The cumulative number of coughs per cumulative dose of mannitol (CDR), cumulative provocative dose of mannitol to cause at least 5 coughs, and the maximal number of coughs provoked by any single mannitol dose. The test was repeated in 26 subjects after 3-7 days.

Results

CDR showed the best repeatability with an intraclass correlation coefficient of 0.829. Gender was the o

SUBMITTER: Nurmi HM 

PROVIDER: S-EPMC11604684 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature