A vaccine platform targeting lung-resident memory CD4⁺ T-cells provides protection against heterosubtypic influenza infections in mice and ferrets.

ABSTRACT: Lung tissue-resident memory T (T_RM) cells induced by influenza vaccination are crucial for heterosubtypic immunity upon re-exposure to the influenza virus, enabling rapid and robust responses upon reactivation. To enhance the efficacy of influenza vaccines, we induce the generation of lung T_RM cells following intranasal vaccination with a commercial influenza vaccine adjuvanted with NexaVant (NVT), a TLR3 agonist-based adjuvant. We demonstrate that intranasal immunization with the NVT-adjuvanted vaccine provides improved protection against influenza virus infections by inducing the generation of CD4⁺ T_RM cells in the lungs in a type I interferon-dependent manner. These pulmonary CD4⁺ T_RM cells provide potent mucosal immunity

SUBMITTER: Ko KH 

PROVIDER: S-EPMC11604757 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature