Role of human plasma metabolites in prediabetes and type 2 diabetes from the IMI-DIRECT study.

ABSTRACT:

Aims/hypothesis

Type 2 diabetes is a chronic condition that is caused by hyperglycaemia. Our aim was to characterise the metabolomics to find their association with the glycaemic spectrum and find a causal relationship between metabolites and type 2 diabetes.

Methods

As part of the Innovative Medicines Initiative - Diabetes Research on Patient Stratification (IMI-DIRECT) consortium, 3000 plasma samples were measured with the Biocrates AbsoluteIDQ p150 Kit and Metabolon analytics. A total of 911 metabolites (132 targeted metabolomics, 779 untargeted metabolomics) passed the quality control. Multivariable linear and logistic regression analysis estimates were calculated from the concentration/peak areas of each metabolite as an explanatory variable and the glycaemic status as

SUBMITTER: Sharma S 

PROVIDER: S-EPMC11604760 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature