MRI detection of free-contrast agent nanoparticles.

ABSTRACT:

Purpose

The integration of nanotechnology into biomedical imaging has significantly advanced diagnostic and theranostic capabilities. However, nanoparticle detection in imaging relies on functionalization with appropriate probes. In this work, a new approach to visualize free-label nanoparticles using MRI and MRS techniques is described, consisting of detecting by ¹H CSI specific proton signals belonging to the components naturally present in most of the nanosystems used in preclinical and clinical research.

Methods

Three different nanosystems, namely lipid-based micelles, liposomes, and perfluorocarbon-based nanoemulsions, were synthesized, characterized by high resolution NMR and then visualized by ¹H CSI at 300 MHz. Subsequently the best ¹

SUBMITTER: Garello F 

PROVIDER: S-EPMC11604830 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature