A blueprint for broadly effective bacteriophage-antibiotic cocktails against bacterial infections.

ABSTRACT: Bacteriophage (phage) therapy is a promising therapeutic modality for multidrug-resistant bacterial infections, but its application is mainly limited to personalized therapy due to the narrow host range of individual phages. While phage cocktails targeting all possible bacterial receptors could theoretically confer broad coverage, the extensive diversity of bacteria and the complexity of phage-phage interactions render this approach challenging. Here, using screening protocols for identifying "complementarity groups" of phages using non-redundant receptors, we generate effective, broad-range phage cocktails that prevent the emergence of bacterial resistance. We also discover characteristic interactions between phage complementarity groups and particular antibiotic classes, facilitating the

SUBMITTER: Kim MK 

PROVIDER: S-EPMC11604943 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature