Unraveling the heart-brain axis: shared genetic mechanisms in cardiovascular diseases and Schizophrenia.

ABSTRACT: The comorbidity between cardiovascular diseases (CVD) and schizophrenia (SCZ) has attracted widespread attention from researchers, with shared genetic causes potentially providing important insights into their association. This study conducted a comprehensive analysis of genetic data from 17 types of CVD and SCZ using genome-wide multi-trait association studies (GWAS), employing statistical methods such as LDSC, MTAG, LAVA, and bidirectional Mendelian randomization to explore global and local genetic correlations and identify pleiotropic single nucleotide variants (SNVs). The analysis revealed a significant genetic correlation between CVD and SCZ, identifying 842 potential pleiotropic single nucleotide variants (SNVs) and multiple associated biological pathways. Notably, genes such as TRIM

SUBMITTER: Shen J 

PROVIDER: S-EPMC11605010 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature