Prestin in Human Perilymph, Cerebrospinal Fluid, and Blood as a Biomarker for Hearing Loss.

ABSTRACT:

Objective

Determining the concentration of prestin in human blood, cerebrospinal fluid (CSF), and perilymph (PL), and evaluating its suitability as a clinical biomarker for sensori-neural hearing loss (SNHL).

Study design

Human blood, CSF, and PL samples were intraoperatively collected from 42 patients with tumors of the internal auditory canal or with intracochlear tumors undergoing translabyrinthine or middle fossa tumor removal. Prestin concentration was measured using enzyme-linked immunosorbent assay and linear regression analyses were performed to investigate its associations with audiological as well as vestibular test results.

Setting

Tertiary referral center.

Results

The median prestin concentration in blood samples of the 42 study participants (26 wom

SUBMITTER: Gadenstaetter AJ 

PROVIDER: S-EPMC11605028 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature