Racial Differences in Systemic Immune Parameters in Individuals With Lung Cancer.

ABSTRACT: Racial and ethnic disparities in the presentation and outcomes of lung cancer are widely known. To evaluate potential factors contributing to these observations, we measured systemic immune parameters in Black and White patients with lung cancer. Patients scheduled to receive cancer immunotherapy were enrolled in a multi-institutional prospective biospecimen collection registry. Clinical and demographic information were obtained from electronic medical records. Pretreatment peripheral blood samples were collected and analyzed for cytokines using a multiplex panel and for immune cell populations using mass cytometry. Differences between Black and White patients were determined and corrected for multiple comparisons. A total of 187 patients with NSCLC (Black, 19; White, 168) were included in

SUBMITTER: von Itzstein MS 

PROVIDER: S-EPMC11605181 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature