Ontology highlight
ABSTRACT:
SUBMITTER: Tonon G
PROVIDER: S-EPMC1160520 | biostudies-literature | 2005 Jul
REPOSITORIES: biostudies-literature
Tonon Giovanni G Wong Kwok-Kin KK Maulik Gautam G Brennan Cameron C Feng Bin B Zhang Yunyu Y Khatry Deepak B DB Protopopov Alexei A You Mingjian James MJ Aguirre Andrew J AJ Martin Eric S ES Yang Zhaohui Z Ji Hongbin H Chin Lynda L Depinho Ronald A RA
Proceedings of the National Academy of Sciences of the United States of America 20050627 27
Lung cancer is the leading cause of cancer mortality worldwide, yet there exists a limited view of the genetic lesions driving this disease. In this study, an integrated high-resolution survey of regional amplifications and deletions, coupled with gene-expression profiling of non-small-cell lung cancer subtypes, adenocarcinoma and squamous-cell carcinoma (SCC), identified 93 focal copy-number alterations, of which 21 span <0.5 megabases and contain a median of five genes. Whereas all known lung ...[more]