Potential Probiotic Properties and Complete Genome Analysis of <i>Limosilactobacillus reuteri</i> LRA7 from Dogs.

ABSTRACT: This study aimed to isolate and screen canine-derived probiotics with excellent probiotic properties. Strain characterization was conducted using a combination of in vitro and in vivo probiotic characterization and safety assessments, as well as complete genome analysis. The results showed that Limosilactobacillus reuteri LRA7 exhibited excellent bacteriostatic and antioxidant activities. The survival rate at pH 2.5 was 79.98%, and the viable counts after exposure to gastrointestinal fluid and 0.5% bile salts were 7.77 log CFU/mL and 5.29 log CFU/mL, respectively. The bacterium also exhibited high hydrophobicity, self-coagulation, and high temperature tolerance, was negative for hemolysis, and was sensitive to clindamycin. In vivo studies in mice showed that the serum superoxide dis

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC11605243 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature