CD4⁺CD8α^low T Cell Clonal Expansion Dependent on Costimulation in Patients With Rheumatoid Arthritis.

ABSTRACT:

Objective

CD4⁺CD8⁺ T cells are increased in patients with rheumatoid arthritis (RA). They are not only associated with joint erosions in established disease but are also present in the preclinical stages of RA. This study aims to further investigate their expansion in the context of T cell clonality in patients with RA, as well as their responsiveness to T cell-targeted treatment.

Methods

Single-cell RNA (scRNA) and single-cell T cell receptor (TCR) sequencing data were used to determine coreceptor expression and TCR sequences to assess the clonality of CD4⁺CD8⁺ T cells in patients with RA (n = 3) and healthy controls (n = 2). Peripheral CD4⁺CD8⁺ T cells and their subpopulations were measured in patients with

SUBMITTER: Beck F 

PROVIDER: S-EPMC11605268 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature