Population pharmacokinetic study of the effect of polymorphisms in the ABCB1 and CES1 genes on the pharmacokinetics of dabigatran.

ABSTRACT:

Purpose

The impact of genetic polymorphisms in the ABCB1 and CES1 genes on dabigatran plasma concentrations remains a subject of debate, and the purpose of this study was to quantitatively assess the effects of genetic polymorphisms on dabigatran esters in healthy Chinese subjects employed a population pharmacokinetic (PopPK) approach.

Methods

In total, 1,926 pharmacokinetic (PK) samples from 123 healthy individuals who were given 150 mg of dabigatran orally during a fasting state or postprandially were analyzed using the PopPK model. A two-compartment model with first-order absorption was found to adequately describe the PK data.

Results

The results showed that covariates food intake and ABCB1 SNP rs4148738 were shown to have statistically significant impacts. Specif

SUBMITTER: Yang Z 

PROVIDER: S-EPMC11605329 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature