Group Social Dynamics in a Seminatural Setup Reflect the Adaptive Value of Aggression in Male Mice.

ABSTRACT: Maladaptive aggression in humans is associated with several psychiatric conditions and lacks effective treatment. Nevertheless, tightly regulated aggression is essential for survival throughout the animal kingdom. Studying how social dominance hierarchies regulate aggression and access to resources in an enriched environment (EE) can narrow the translational gap between aggression in animal models and normal and pathological human behavior. The social box is a seminatural setup for automatic and prolonged monitoring of mouse group dynamics. We utilized the social box to decipher tradeoffs between aggression, social avoidance, resource allocation, and dominance in 2 mouse models of increased aggression: 1) a model of early exposure to an EE and 2) a model of oxytocin receptor deficiency (Ox

SUBMITTER: Anpilov S 

PROVIDER: S-EPMC11605369 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature