The association of motor reserve and clinical progression in Parkinson's disease.

ABSTRACT:

Objective

To explore the association of motor reserve (MR) and clinical progression in Parkinson's disease.

Methods

This longitudinal study using data from the Parkinson's progression markers initiative. Patients with de novo PD who underwent dopamine transporter scans at baseline and finished at least five years clinical follow-up assessments (including motor, cognitive, and non-motor symptoms) were included. The individual MR of PD patients were estimated based on initial motor deficits and striatal dopamine depletion using a residual model. Linear mixed-effects models (LME) were performed to examine the associations of baseline MR and clinical progression.

Results

A total of 303 de novo PD patients were included and the mean follow-up time was 8.95 years. Results o

SUBMITTER: Bai X 

PROVIDER: S-EPMC11605422 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature