High-resolution perfusion imaging in rodents using pCASL at 9.4 T.

ABSTRACT: Adequate perfusion is critical for maintaining normal brain function and aberrations thereof are hallmarks of many diseases. Pseudo-Continuous Arterial Spin Labeling (pCASL) MRI enables noninvasive quantitative perfusion mapping without contrast agent injection and with a higher signal-to-noise ratio (SNR) than alternative methods. Despite its great potential, pCASL remains challenging, unstable, and relatively low-resolution in rodents - especially in mice - thereby limiting the investigation of perfusion properties in many transgenic or other relevant rodent models of disease. Here, we address this gap by developing a novel experimental setup for high-resolution pCASL imaging in mice and combining it with the enhanced SNR of cryogenic probes. We show that our new experimental setup allow

SUBMITTER: Pires Monteiro S 

PROVIDER: S-EPMC11605498 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature