Pro-inflammatory activity of Cutibacterium acnes phylotype IA₁ and extracellular vesicles: An in vitro study.

ABSTRACT: Acne is a chronic inflammatory skin condition that involves Cutibacterium acnes (C. acnes), which is classified into six main phylotypes (IA₁, IA₂, IB, IC, II and III). Acne development is associated with loss of C. acnes phylotype diversity, characterised by overgrowth of phylotype IA₁ relative to other phylotypes. It was also shown that purified extracellular vesicles (EVs) secreted by C. acnes can induce an acne-like inflammatory response in skin models. We aimed to determine if the inflammatory profile of EVs secreted by C. acnes phylotype IA₁ from an inflammatory acne lesion was different from C. acnes phylotype IA₁ from normal skin, thus playing a direct role in the severity of inflammation. EVs were produced in vitro after cultu

SUBMITTER: Cheung CT 

PROVIDER: S-EPMC11605500 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature