Genetics of Latin American Diversity Project: Insights into population genetics and association studies in admixed groups in the Americas.

ABSTRACT: Latin Americans are underrepresented in genetic studies, increasing disparities in personalized genomic medicine. Despite available genetic data from thousands of Latin Americans, accessing and navigating the bureaucratic hurdles for consent or access remains challenging. To address this, we introduce the Genetics of Latin American Diversity (GLAD) Project, compiling genome-wide information from 53,738 Latin Americans across 39 studies representing 46 geographical regions. Through GLAD, we identified heterogeneous ancestry composition and recent gene flow across the Americas. Additionally, we developed GLAD-match, a simulated annealing-based algorithm, to match the genetic background of external samples to our database, sharing summary statistics (i.e., allele and haplotype frequencies) wi

SUBMITTER: Borda V 

PROVIDER: S-EPMC11605695 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature