Individualized Prediction for Risk of Recurrence in Stage I/II Melanoma Patients With Negative Sentinel Lymph Node.

ABSTRACT:

Background

Despite the favorable prognosis of AJCC stage I/II melanoma patients, up to 20%-30% will develop metastases. Our objective is to predict long-term risk (probability) of recurrence in early-stage melanoma patients.

Methods

A Risk Score to predict long-term recurrence was developed using Cox regression based on 2668 patients. Five clinicopathological risk factors were included. The association of the Risk Score with the risk of recurrence was evaluated using parametric models (exponential, Weibull, and Gompertz models) and compared to the Cox model using the Akaike information criterion. The discrimination of the model was measured by time-dependent ROC analyses. A calibration curve was used to evaluate the agreement between predicted and observed recurrence probabi

SUBMITTER: Chang SC 

PROVIDER: S-EPMC11605731 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature