System Genetics Analysis Reveals Sex Differences in Human Aortic Smooth Muscle Gene Expression.

ABSTRACT: Coronary artery disease (CAD) is one of the leading causes of death worldwide. The buildup of atherosclerotic plaque, including lipids and cellular waste, characterizes this disease. Smooth muscle cells (SMCs) can migrate and proliferate to form a fibrous cap that stabilizes the atherosclerotic plaque in response to plaque buildup. However, in some severe cases, the fibrous cap is unable to prevent plaque rupture, which can lead to a thrombotic event causing a stroke or myocardial infarction. Studies have been conducted to identify genes associated with this disease. However, the influence of sex on CAD risk is poorly understood due to the complexity of the disease and the lack of women in clinical studies. This study is investigated with a unique collection of human aortic smooth muscle c

SUBMITTER: Meng SL 

PROVIDER: S-EPMC11605743 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature