Mutual Interactions of Silymarin and Colon Microbiota in Healthy Young and Healthy Elder Subjects.

ABSTRACT:

Scope

This multi-omic study investigates the bidirectional interactions between gut microbiota and silymarin metabolism, highlighting the differential effects across various age groups. Silymarin, the extract from Silybum marianum (milk thistle), is commonly used for its hepatoprotective effects.

Methods and results

An in vitro fermentation colon model was used with microbiota from 20 stool samples obtained from healthy donors divided into two age groups. A combination of three analytical advanced techniques, namely proton nuclear magnetic resonance (¹H NMR), next-generation sequencing (NGS), and liquid chromatography-mass spectrometry (LC-MS) was used to determine silymarin microbial metabolites over 24 h, overall metabolome, and microbiota composition. Silymarin

SUBMITTER: Tomisova K 

PROVIDER: S-EPMC11605779 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature