Baseline Dual-Energy Computed Tomography Urate Volume Predicts Fulfillment of Gout Remission After Two Years of Urate-Lowering Therapy.

ABSTRACT:

Objective

This study aimed to identify variables that predict gout remission in people with erosive gout receiving urate-lowering therapy.

Methods

We analyzed data from a two-year, double-masked randomized-controlled trial of people with erosive gout, randomized to a serum urate target of <0.20 mmol/L or <0.30 mmol/L using oral urate-lowering therapies. All participants had dual-energy computed tomography (DECT) scans of the feet and ankles at baseline. The proportion of participants achieving gout remission according to the 2016 preliminary gout remission criteria and simplified gout remission criteria (without the patient reported outcomes) was analyzed. Logistic regression models were used to evaluate predictors of gout remission in year 2.

Results

The preliminary

SUBMITTER: Tabi-Amponsah AD 

PROVIDER: S-EPMC11605780 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature