Interferon-α as a biomarker to predict renal outcomes in lupus nephritis.

ABSTRACT:

Objective

To determine if serum interferon (IFN)-α levels at the time of a lupus nephritis (LN) flare are associated with renal outcomes.

Methods

Patients with an LN flare who had a preflare estimated glomerular filtration rate (eGFR) ≥60 mL/min were included in the study. The following outcomes were ascertained: (1) Time to first and second LN flares during follow-up, (2) Time to a sustained decline in eGFR by 30% and 50%, and progression to end-stage renal disease (ESRD, <15 mL/min), and (3) Time to an adverse renal event (≥2 renal flares and/or at least a 30% sustained decline in eGFR during follow-up). Serum IFN-α was measured by Simoa.

Results

92 patients with active LN were included in the study. Elevated serum baseline levels of IFN-α predicted poor renal outco

SUBMITTER: Whittall Garcia LP 

PROVIDER: S-EPMC11605838 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature