Impact of pharmacist-led aminoglycoside stewardship: a 10-year observational study.

ABSTRACT:

Background

Aminoglycosides are crucial for treating multidrug-resistant gram-negative infections and endocarditis. However, aminoglycosides are associated with significant risks of nephrotoxicity, necessitating careful dose selection and therapeutic drug monitoring. Therapeutic drug monitoring is essential for minimizing risk; however, few institutions routinely perform it. This study aimed to assess the impact of a pharmacist-driven therapeutic drug monitoring intervention on aminoglycoside usage trends and clinical outcomes.

Methods

This retrospective cohort study included 263 patients treated with aminoglycosides between 2014 and 2023. A pharmacist-led therapeutic drug monitoring intervention began in 2017, focusing on monitoring renal function, documenting patient weight

SUBMITTER: Shinoda Y 

PROVIDER: S-EPMC11605850 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature