Time-dependent changes in genome-wide gene expression and post-transcriptional regulation across the post-death process in silkworm.

ABSTRACT: Despite death marking the end of life, several gene expression and miRNA-mediated post-transcriptional regulation events may persist or be initiated. The silkworm (Bombyx mori) is a valuable model for exploring life processes, including death. In this study, we combined transcriptomics and miRNAomics analyses of young, old, and post-mortem silkworms across the entire process after death to unravel the dynamics of gene expression and miRNA-mediated post-transcriptional regulation. In total, 171 genes exhibited sustained differential expression in post-mortem silkworms compared to the pre-death state, which are primarily involved in nerve signalling, transport, and immune response. Post-mortem time-specific genes were associated with cell cycle regulation, thermogenesis, immunity, and zinc i

SUBMITTER: Yang LY 

PROVIDER: S-EPMC11605879 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature